18 positron emission tomography/computerised tomography (FDG Family pet/CT) is commonly used in the management of RGS3 patients with lymphomas and is recommended for both initial staging and response assessment after treatment in patients with diffuse large B-cell lymphoma and Hodgkin lymphoma. PET after induction treatment would seem to predict a shorter progression-free survival. 1 Introduction Follicular lymphoma (FL) is one of the most common types of lymphoma representing around 25% of adult non-Hodgkin lymphomas (NHLs) worldwide [1]. FL advancement is highly variable with differences in clinical display histological appearance clinical response and behavior to therapy. Indeed although some Gleevec FL sufferers achieve prolonged full remission (CR) various other knowledge iterative relapses with or without histological change Gleevec into a high-grade lymphoma (25-60%) [2 3 Treatment options including watchful waiting external radiotherapy chemotherapy monoclonal antibodies radioimmunotherapy (RAIT) and biologic therapies are guided by clinical features the extent of disease at presentation and prognostic indices such as the FL international prognostic index (FLIPI) [4-6]. In order to segregate between patients with an indolent FL from those with more aggressive disease risk stratification and identifying factors predictive of survival are of major desire for this disease. 18 positron emission tomography (FDG PET/CT) is usually a noninvasive whole-body tri-dimensional imaging Gleevec technique. FDG PET/CT is commonly used in the management of patients with lymphomas especially for initial staging and response assessment at the end of treatment in patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). Despite the now well recognized FDG avidity of FL the use of FDG PET/CT is not recommended in standard practice [7-9]. Herein we review using recent publications the interest of FDG PET/CT in FL and the potential of new PET tracers such as radio-labeled monoclonal antibodies (MAbs). 2 FDG PET for Initial Staging In order to stage the disease (Ann Arbor classification) and calculate the FLIPI Gleevec score initial evaluation for FL includes physical examination haematological and biochemical analysis CT imaging of chest stomach and pelvis plus bone marrow biopsy [10]. Outside clinical trial where FDG PET/CT is recommended before therapy principally to improve posttherapy evaluation FDG PET/CT at time of diagnosis is not routinely performed [7]. Nevertheless FDG PET/CT at diagnosis may be of interest not only for disease staging or posttherapy evaluation but also to guide the therapeutic strategy in FL. A primary example of the power of FDG PET/CT would be with an FL patient presenting at diagnosis with conventionally staged localized disease. FDG PET/CT could be of great interest to confirm that there is a unique site involved. After that the usage of radiation rather than a wrist watch and wait around option could be an acceptable therapeutic approach. Many retrospective research show that FDG Family pet/CT detects even more lesions than CT scans specifically lymph node participation and extranodal lesions. The power of FDG-PET to judge bone tissue marrow infiltration in sufferers with lymphoma in addition has been investigated thoroughly. Prior studies demonstrated that FDG-PET includes a high potential to identify bone marrow participation in high-grade malignant lymphoma but acquired low awareness for the recognition of diffuse bone tissue marrow infiltration in low-grade NHL specifically FL [11]. Not surprisingly in retrospective research preliminary FDG PET evaluation customized Ann Arbor staging in 11 to 31% of sufferers particularly for sufferers regarded as early stage on regular evaluation [12-19]. In some 45 neglected FL sufferers Le Dortz et al. reported Gleevec that 11% of sufferers regarded early stage (I/II) pursuing regular evaluation (physical evaluation CT and bone tissue marrow biopsy) had been found to become having advanced III/IV stage when FDG Family pet/CT was considered [20]. This Gleevec factor appears influential in choosing an optimal initial therapeutic strategy. A second major value of FDG PET/CT at diagnosis is to guide diagnostic biopsy in the most FDG-avid site of disease in FL patients showing clinical biochemical or anatomical indicators of aggressive transformation. Histological transformation of indolent lymphoma is usually a dramatic event that occurs in 5-10% of patients and carries a poor prognosis [21]. Identification of patients with histological transformation often prospects to a change in therapeutic management requiring intensified immuno-chemotherapy regimens. Moreover patients with histological transformation achieving a complete response after intensified chemotherapy can experience prolonged survival.